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Kiran Patil, outgoing EMBL Group Leader who’s now based at the MRC Toxicology Unit at the University of Cambridge, who co-led the study, said: “It was surprising that the majority of the new interactions we saw between bacteria and drugs were the drugs accumulating in the bacteria, because up until now biotransformation was thought to be the main way that bacteria affect the availability of drugs.” While earlier research has shown bacteria can chemically modify drugs, when the scientists studied these interactions further, they found that for 17 of the 29 new interactions, the drug accumulated within the bacteria without being modified. They found 70 interactions between the bacteria and the drugs studied – of which 29 had not been previously reported. The researchers tested how each of the 15 drugs interacted with the selected bacterial strains – a total of 375 bacteria–drug tests. The drugs were chosen to represent a range of different types of common drugs, including antidepressant medications, which are known to affect individuals dissimilarly and cause side effects such as gut problems and weight gain. In this study, the researchers grew 25 common gut bacteria and studied how they interacted with 15 drugs that are taken orally. The composition of bacterial species varies significantly between people and has previously been shown to be associated with a wide range of conditions including obesity, immune response, and mental health. The human gut naturally contains communities of hundreds of different species of bacteria, which are important in health and disease, called the gut microbiome. This could change the effectiveness of the drug both directly, as the accumulation could reduce the availability of the drug to the body, and indirectly, as altered bacterial function and composition could be linked to side-effects.
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This study, led by researchers from the Medical Research Council (MRC) Toxicology Unit at the University of Cambridge and the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, is the first to show that certain species of gut bacteria accumulate human drugs, altering the types of bacteria and their activity. It is known that bacteria can chemically modify some drugs, a process known as biotransformation. These interactions – seen for a variety of medications, such as depression, diabetes, and asthma drugs – could help researchers to better understand individual differences in drug effectiveness and side-effects, according to the study published in Nature. Credit: Aleksandra KrolikĬommon medications can accumulate in gut bacteria, a new study has found, altering bacterial function and potentially reducing the effectiveness of the drug. Then I will post a few from the beginning and how we got here.Common medications accumulate in gut bacteriaĭrug accumulation may reduce drug effectiveness and alter the gut microbiomeĬommonly used drugs accumulate in human gut bacteria, which can affect the drugs' effectiveness and change the bacteria's metabolism.
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So I will start this project off of where we are at right now, we are getting close to going for first test drive tomorrow, just waiting for new Hondata S300 to be installed tonight, and a few small jobs to do before we can go cruising. Sorry for the English, Mein Deutsch ist noch nicht so gut. Matt and I differ a bit in color palates, but overall we have a similar vision of what the final product should be. So we set out on tackling removing the old conversion and installing our conversion kit, MCM conversion kit that retains stock suspension and geometry. I prefer the Honda D16 Sohc and a steel front. I bought the pickup as a rolling incomplete project that had a Honda K20 with an extended flip front. It has been a long build as the base, a 1968 Mini Pickup the shell needed a fair amount of metal work before we could start. I just wanted to share a build that I am completing for a very good friend/customer in Massachusetts, USA.